DNA Repair Therapies for Ovarian Cancer Dream Team - Stand Up To Cancer

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SU2C–Ovarian Cancer Research Alliance–National Ovarian Cancer Coalition Ovarian Cancer Dream Team: DNA Repair Therapies for Ovarian Cancer

Grant Term: July 2015–June 2019

The SU2C-Ovarian Cancer Research Fund Alliance-National Ovarian Cancer Coalition Dream Team focused on developing new therapies that target DNA repair and applying them to a much larger group of women, beyond those with BRCA1 and BRCA2 mutations. By screening for inherited mutations in genes linked to DNA repair, the team worked to identify women at high risk for ovarian cancer for whom preventative measures may be lifesaving. With a combined focus on treatment and prevention, the program delivered near-term ovarian cancer patient benefit.

ABOUT THIS TEAM’S RESEARCH

Ovarian cancer is usually diagnosed at an advanced stage, when it is hard to treat, and death rates are high. Cancers with certain types of DNA repair defects are responsive to targeted therapies, such as drugs called PARP inhibitors.
The Dream Team brought together internationally renowned experts to focus on developing new therapies that target DNA repair and on expanding the use of drugs called PARP inhibitor to a much larger group of women. In addition, by screening for inherited mutations in genes linked to DNA repair, the team worked to find ways to identify women at higher risk for ovarian cancer. The team took a three-pronged approach to its goals:
1. Identify ovarian cancers that are likely to respond to DNA repair therapies.
2. Evaluate, in three clinical trials, new drug combinations that may sensitize ovarian tumors to PARP inhibitors.
3. Develop web-based genetic testing and counseling strategies and test surgical prevention models.

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